DRAFT
Memorandum of Understanding
for the implementation of a European Concerted Research
designated as
COST Action 26
"OBSTRUCTIVE SLEEP APNEA"

The signatories to this ?Memorandum of Understanding', declaring their common intention to
participate in the concerted Action referred to above and described in the ?Technical Annex to the
Memorandum', have reached the following understanding:
1. The Action will be carried out in accordance with the provisions of document COST 400/01 ?Rules and Procedures for Implementing COST Actions' the contents of which the Signatories are fully aware of.
2. The main objectives of the COST Action B26 are:
? - To assess the role of the Obstructive Sleep Apnea Syndrom (OSAS) as a possible cause of increased cardiovascular risk.
? - To coordinate studies on pathogenetic mechanisms of increased cardiovascular risk of OSAS (i.e., inflammation, oxidative??? stress,??endothelial?????? dysfunction, metabolic derangements, altered autonomic control associated with exposure to intermittent hypoxia).
3. The economic dimension of the activities carried out under the Action has been estimated, on the basis of information available during the planning? of the Action, at EURO 10 Million in 2004 prices.
4. The Memorandum of Understanding will take effect on being signed by at least five Signatories.
5. The Memorandum of Understanding will remain in force for a period of four years, calculated from the date of the first meeting of the Management Committee, unless the duration of the Action is modified according to the provisions of Chapter 6 of the document referred to in Point 1 above.